I never watched the show and wouldn't know her from Angelica Huston, but I would think that it's okay as long as (1) it's crossed well, and (2) it's part of a good theme. Angelica is a guessable name, but Pickles is not without the theme or crosses to help me. That is, unless the theme were something where "pickles" was important, if the P were crossed with ?ANDO "Tree also known as the trembling giant," I would have no way to know whether her name was Pickles, Rickles, Nickles, etc. (except maybe to guess that a kids show would use Pickles as a name because pickles are funny). Of course, I'm not the editor, but as a solver, that's where I'd come down.
Cheers,
- VB